Absorption of vitamin D3-3H in control subjects and patients with intestinal malabsorption.
نویسندگان
چکیده
منابع مشابه
Comparative absorption of vitamin D3 and 25-hydroxyvitamin D3 in intestinal disease.
The absorption of simultaneously administered equimolar doses of 14C vitamin D3 and 3H 25 hydroxyvitamin D3 (25-OH-D3) has been studied in controls and patients with a variety of gastrointestinal disorders. As assessed from peak radioactivity in the serum and from faecal excretion of radioactivity, malabsorption of both vitamin D3 and 25-OH-D3 occurred in patients with steatorrhoea. Malabsorpti...
متن کاملFaecal tritium excretion after intravenous administration of 3H-25-hydroxyvitamin D3 in control subjects and in patients with malabsorption.
Faecal tritium excretion after intravenous 3H-25-hydroxyvitamin D3 administration was measured in three control subjects and in six patients with small intestine resection or bypass. The mean daily faecal tritium excretion over four to six days ranged from 0.8-1.6% of the injected dose in the controls (mean 1.2) and 0.9-6.8% in the patients (mean 3.7). There was a significant positive correlati...
متن کاملChanges in plasma half-life and clearance of 3H-25-hydroxyvitamin D3 in patients with intestinal malabsorption.
The plasma disappearance of intravenously administered tracer doses of tritium-labelled 25-hydroxyvitamin D3 (25OHD3) wa studied in six normal subjects and in 15 patients with intestinal malabsorption. The plasma half-life was significantly shorter and the clearance rate significantly greater in the group with malabsorption compared with the controls. One explanation for this increased eliminat...
متن کاملVitamin D absorption in healthy subjects and in patients with intestinal malabsorption syndromes.
We developed a test procedure for the clinical evaluation of the absorption of vitamin D. Serum vitamin D concentrations were evaluated in seven patients with intestinal fat malabsorption syndromes and in seven healthy, normal subjects, after being given a single oral dose of 50,000 IU (1.25 mg) vitamin D2. In the normal subjects, serum vitamin D concentrations rose from a baseline of less than...
متن کاملVitamin B12 absorption--a study of intraluminal events in control subjects and patients with tropical sprue.
The intraluminal fate of orally administered radioactive vitamin B12 has been studied in control subjects with normal vitamin B12 absorption and those with vitamin B12 malabsorption due to tropical sprue. In control subjects 1 to 21% of the dose was bound to sedimentable material and 37 to 75% was bound to immunoreactive intrinsic factor. In subjects with vitamin B12 malabsorption due to tropic...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 45 1 شماره
صفحات -
تاریخ انتشار 1966